[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 3, Issue 3 (1-2012) ::
Caspian J Intern Med 2012, 3(3): 473-477 Back to browse issues page
Pseudo-cholinesterase polymorphism in Mazandaran province (North of Iran)
Ebrahim Zabihi *, Meisam Shabanzadeh, Sina Arabsheibani, Ali Akbar Moghadamnia, Mahmoud Baradaran
Abstract:   (6978 Views)
Background: Pseudocholinesterase (PChE) polymorphism has been a subject of several pharmacogenetic studies worldwide. The patients with atypical homozygous genotype do not only have reduced serum cholinesterase activities but also their elimination rate for some pharmacologically potent drugs decrease drastically. This study was designed to evaluate the PChE polymorphism in Mazandaran province (northern Iran) for the first time.
Methods: About 5 ml plasma samples were collected from 200 healthy volunteers who visited "Iran Blood Transfusion Organization" centers all across Mazandaran province for blood donation. The PChE activity in presence or absence of dibucain was measured and based on obtained dibucain number (DN) volunteers were categorized to normal homozygous (Eu,u), atypical heterozygous (Eu,a), and atypical homozygous (Ea,a).
Results: The average (±SD) of the PChE activity among the blood donors was 9.14 ± 1.93 IU (ranging from 4.1 to 16.6 IU). Only 2 persons (1%) had DN between 60 to 70 (Eu,a) and no one was categorized in 20Conclusion: According to the findings, only 1% of the sample population had atypical heterozygous phenotype taking into account the experiment precision, the frequency of Ea,u is less than 4%. These findings suggest that the atypical allele frequency in northern Iran's population is probably less than the other regions of Iran and some other countries.
Keywords: Pseudocholinesterase, polymorphism, succinylcholine, mivacurium, Mazandadaran
Full-Text [PDF 145 kb]   (1667 Downloads)    
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zabihi E, Shabanzadeh M, Arabsheibani S, Moghadamnia A A, Baradaran M. Pseudo-cholinesterase polymorphism in Mazandaran province (North of Iran). Caspian J Intern Med. 2012; 3 (3) :473-477
URL: http://caspjim.com/article-1-159-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 3 (1-2012) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4419