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Caspian J Intern Med 2012, 3(3): 496-499 Back to browse issues page
Infective endocarditis mimics ANCA associated glomerulonephritis
Mohammad Reza Ardalan *, Matias Trillini
Abstract:   (13192 Views)
Background: Sub-acute bacterial endocarditis (SBE) rarely presents with features of a small vessel vasculitis. Patients with SBE can also develop multiple serological abnormalities including ANCA. In this report, we present a case of infective endocarditis mimicked ANCA associated glomerulonephritis.
Case presentation: A 57-year old male with a clinical picture of rapidly progressive renal failure (RPGN) and positive seology for PR3-ANCA (C-ANCA) was referred to our hospital. The renal histology findings were compatible with focal and segmental glomerular necrosis. After receiving corticosteroid therapy, the patient became febrile and his general condition worsened. Cardiac ultrasound echocardiographic study disclosed multiple large vegetations on the aortic valve. After appropriate antibiotic therapy and valvular surgery, the patient’s condition improved and his serum creatinine reached 1.7 mg/d.
Conclusion: Misdiagnosis of SBE as ANCA-associated vasculitis and an inappropriate immunosuppressive therapy can have catastrophic consequences.
Keywords: Sub-acute bacterial endocarditis, ANCA, Vasculitis, Glomerulonephritis
Full-Text [PDF 398 kb]   (2203 Downloads)    
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15
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Ardalan M R, Trillini M. Infective endocarditis mimics ANCA associated glomerulonephritis. Caspian J Intern Med. 2012; 3 (3) :496-499
URL: http://caspjim.com/article-1-163-en.html


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Volume 3, Issue 3 (1-2012) Back to browse issues page
Caspian Journal of Internal Medicine
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