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:: Volume 11, Issue 2 (3-2020) ::
Caspian J Intern Med 2020, 11(2): 150-154 Back to browse issues page
Comparison of CD4+ and CD8+ T- lymphocyte in Helicobacter pylori-negative functional dyspepsia
Leila Vahedi * , Sousan Mirnajd Gerami , Kourosh Masnadi-Shirazi , Seyed Kazem Mirinezhad , Shabnam Salehi , Monireh Halimi
Liver and Gastrointestinal Disease Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. , Vahedi.l49@gmail.com
Abstract:   (3352 Views)
Background: Functional dyspepsia (FD) is the most common gastrointestinal disorder with several symptoms such as stomach pain and abdominal bloating. The aim of this study was to investigate and compare CD4+ and CD8+ in the Helicobacter pylori-negative functional dyspepsia and control groups.
Methods: Sixty one patients (35 patients with stomach pain and 26 with abdominal bloating), and 30 controls were reviewed based on the quantity of CD4+ and CD8+ T-cells isolated from gastric mucosa biopsy samples. The comparison between variables was analyzed with a chi-square or Fisher’s exact test and logistic regression analyses. P<0.05 and odds ratio (OR) with a 95% confidence interval demonstrated statistical significance.
Results: A significant difference was observed between two-group patients and control group based on CD4+ and CD8+ presence, respectively (P=0.003, P=0.008). Furthermore, there was a significant difference between stomach pain-patients and control group with regard to CD4 count (P=0.01) and between abdominal bloating-patients and control group with regard to CD8 count (P=0.002). There was a decrease in both CD4+ and CD8+ T-cells in gastric mucosa in patients with FD with a significant reduction in the stomach pain-patients and abdominal bloating-patients in the number of CD4+ and CD8+ T-cells, respectively.
Conclusion: These results indicated that the role of immunology in the absence of the CD4+ and CD8+ T-cells in the gastric mucosa may have a protective role against FD.
Keywords: Functional dyspepsia, Comparison, T-lymphocytes, Helicobacter pylori, CD4, CD8.
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Type of Study: Original Article | Subject: Gastroentrology
Received: 2019/05/15 | Accepted: 2019/10/7 | Published: 2020/04/22
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Vahedi L, Mirnajd Gerami S, Masnadi-Shirazi K, Mirinezhad S K, Salehi S, Halimi M. Comparison of CD4+ and CD8+ T- lymphocyte in Helicobacter pylori-negative functional dyspepsia. Caspian J Intern Med 2020; 11 (2) :150-154
URL: http://caspjim.com/article-1-1904-en.html

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Volume 11, Issue 2 (3-2020) Back to browse issues page
Caspian Journal of Internal Medicine
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