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Evaluation of inhibitor antibodies in haemophilia A population
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Hassan Mahmoodi Nesheli   , Amereh Hadizadeh , Ali Bijani |
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Abstract: (7498 Views) |
Background: Inhibitory antibody to exogenous Factor VIII (FVIII) is a major complication of hemophilia treatment. This study was conducted to determine the prevalence of inhibitor antibody directed against FVIII.
Methods: From May 2010 to May 2011, 52 patients with severe hemophilia A admitted in Amirkola Children’s Hospital were evaluated. Those who had abnormal mixing study, antibody against FVIII were measured. Data were collected and analyzed.
Results: The age range of the patients was 4-60 years. The inhibitor antibody was seen in 9 (17.3%) patients. The mean age of patients with inhibitor at the time of diagnosis was 10.22 years (ranged 4-31 years). Old patients had more hemarthrosis than young patients. The mean level of inhibitor antibody was 8.47 Bethesda (ranged 2.3-29). Six patients had inhibitor antibody level ?5 Bethesda unit and three patients had inhibitor antibody level<5 Bethesda unit.
Conclusion: This study showed that the prevalence of inhibitor antibody in young patients is more than the old patients.
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| Keywords: Inhibitory antibodies, concentrated FVIII, hemophilia A, Hemarthrosis |
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Full-Text [PDF 92 kb]
(1804 Downloads)
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Type of Study: Original Article |
Subject:
Infectious Diseases
Received: 2014/01/17 | Accepted: 2014/01/17 | Published: 2014/01/17
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