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:: Volume 12, Issue 2 (3-2021) ::
Caspian J Intern Med 2021, 12(2): 207-215 Back to browse issues page
Rectal Diclofenac versus High-Dose Rectal Acetaminophen in Children: a randomized clinical trial
Houman Hashemian , Marzie Fallah Khodadoost
Pediatric Diseases Research Center (PDRC), Guilan University of Medical Sciences, Rasht, Iran , hashemian@gums.ac.ir
Abstract:   (267 Views)
Background: Fever is the most common complaint among the children admitted to health care centers. The aim of this study was to compare the anti-pyretic effect of diclofenac and high dose acetaminophen suppository in 1 to 6 years old children.
Methods: This double-blind clinical trial study was performed on 1-6-year-old children hospitalized in 17th Shahrivar Teaching Hospital, Rasht, Iran. Children were divided into two groups of 45 using a block randomization design. The first group received a high dose of acetaminophen suppository at a dose of 30 mg/kg and the second group received a diclofenac suppository at a dose of 1 mg/kg. The rectal temperature of the patients was measured using a digital thermometer at the time of drug administration, and one and three hours after that.
Results: 90 children were studied in two groups of 45 each. Temperature changes in the diclofenac group were significantly greater than the acetaminophen group, so from zero to 3 hours after administering diclofenac, the temperature decreased to 1.76±0.95°C. This reduction was lower in acetaminophen group (1.26±0.49°C, P=0.019).
Conclusion: Both acetaminophen and diclofenac suppositories significantly reduced the rectal temperature. However, the effect of rectal diclofenac on reducing temperature is more than rectal acetaminophen.
Keywords: acetaminophen, diclofenac, fever, rectal, suppository
Full-Text [PDF 251 kb]   (78 Downloads)    
Type of Study: Original Article | Subject: Pediatrics
Received: 2020/05/9 | Accepted: 2020/09/8 | Published: 2021/03/30
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Hashemian H, Fallah Khodadoost M. Rectal Diclofenac versus High-Dose Rectal Acetaminophen in Children: a randomized clinical trial. Caspian J Intern Med. 2021; 12 (2) :207-215
URL: http://caspjim.com/article-1-2309-en.html

Volume 12, Issue 2 (3-2021) Back to browse issues page
Caspian Journal of Internal Medicine
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