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:: Volume 12, Issue 4 (9-2021) ::
Caspian J Intern Med 2021, 12(4): 4-0 Back to browse issues page
Prevalence of Occult Hepatitis C Virus Infection in Hemodialysis Patients
Masomeh Bayani , Mohammad Reza Hasanjani Roushan , Mohammad Jafar Soleimani Amiri , Yousef Yahyapour , Soheil Ebrahimpour , Somayeh Akbarzadeh Jelodar *
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran. , Dr.akbarzadeh1@yahoo.com
Abstract:   (89 Views)

Background: Via hemodialysis, viral infections can be transmitted in these patients a new definition of this infection that no increase in liver enzymes, negative HCV-PCR in serum and the presence of virus in the liver and peripheral blood mononuclear cell (PBMC) that called occult hepatitis C virus (HCV) infection (OCI). We decided to examine the prevalence of occult hepatitis C infection on hemodialysis cases.
Methods: The current research  is a cross-sectional study on patients with end-stage renal disease (ESRD) who were at three hemodialysis centers in Mazandaran province in Iran during 2012 - 2014. In this study of 356 patients who were undergoing hemodialysis, 54 patients were excluded due to positive HCV Ab, and the remaining 302 patients were enrolled. The test of all serum samples for HCV-RNA detection of plasma and PBMCs was done by real-time polymerase chain reaction (real-time PCR).
Results: There was a significant association between the duration of dialysis with the prevalence of occult HCV infection (P=0.017). Eight (2.65%) patients were positive for HBs Ag and with OCI, but none of them infected with both hepatitis C and B obviously. Also among total patients, nine patients tested positive for HCV RT-PCR in PBMC that one of them was positive for serum HCV RNA PCR and excluded from the study.
Conclusion: The results showed that eight patients had an OCI. There wasn’t found any association between age and sex with OCI, but there was a significant relationship between the duration of dialysis with the prevalence of OCI.
Keywords: hemodialysis, occult infection, hepatitis C
     
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2020/06/23 | Accepted: 2020/12/6 | Published: 2021/09/19
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Bayani M, Hasanjani Roushan M R, Soleimani Amiri M J, Yahyapour Y, Ebrahimpour S, Akbarzadeh Jelodar S. Prevalence of Occult Hepatitis C Virus Infection in Hemodialysis Patients. Caspian J Intern Med. 2021; 12 (4) :4-0
URL: http://caspjim.com/article-1-2394-en.html


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Volume 12, Issue 4 (9-2021) Back to browse issues page
Caspian Journal of Internal Medicine
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