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:: Volume 12, Issue 4 (9-2021) ::
Caspian J Intern Med 2021, 12(4): 6-0 Back to browse issues page
The association of disease type, pre-transplant hemoglobin level and platelet count with transfusion requirement after autologous hematopoietic stem cell transplantation
Shabnam Tabasi , Sayeh Parkhideh , Elham Roshandel , Samira Karami , Anahita Saeedi , Ali Jabbari , Abbas Hajifathali *
Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , hajifathali@yahoo.com
Abstract:   (73 Views)
Background: Autologous hematopoietic stem cell transplantation (auto-HSCT) has become an effective treatment for a wide range of hematologic and non-hematologic diseases. Patients undergoing HSCT might require multiple platelets and red blood cell (RBC) transfusions during aplasia phase until engraftment, which could profoudly affect patients’ conditions. Identification of risk factors associated with blood products requirements could help in decreasing transfusion-related complications. We evaluated the association of disease type, pre-transplant hemoglobin level, and pre-transplant platelet count with RBC/platelet transfusion requirement after auto-HSCT.
Material and Methods:  In this retrospective study, 329 patients diagnosed with multiple myeloma (MM), Hodgkin disease (HD), and non-Hodgkin lymphoma (NHL) and underwent auto-HSCT were included. The associations of disease type, pre-transplant hemoglobin level, and platelet count with post-transplant packed cell and single-/random-donor platelet transfusions were evaluated.
Results: Our results illustrated that the higher pre-transplant hemoglobin level significantly decreased the post-HSCT requirement for packed cell (IRR=0.81, [CI: 9.73-0.90], P=0.0001), while the pre-transplant platelet showed no significant relationship with platelet requirement after HSCT. HD was associated with increment in packed cell (IRR=2.04, [CI: 1.35-3.08], P=0.001) and single donor platelet (IRR=1.39, [CI:1.09-1.78], P=0.008) requirement after transplant. The trends showed that a higher platelet level led to a lower need for platelet transfusion.
Conclusion:  In conclusion, pre-transplant hemoglobin level could be valuable markers for predicting post-HSCT RBC requirements and might be beneficial for better management of transfusion requirements to minimize the transfusion-related complications. Patients with HD seem to be more prone to blood product requirements post-transplant.
Keywords: Autologous, Hematopoietic stem cell transplantation, Hemoglobin, Platelet, Transfusion
     
Type of Study: Original Article | Subject: Hematology
Received: 2020/07/12 | Accepted: 2021/02/15 | Published: 2021/09/19
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Tabasi S, Parkhideh S, Roshandel E, Karami S, Saeedi A, Jabbari A et al . The association of disease type, pre-transplant hemoglobin level and platelet count with transfusion requirement after autologous hematopoietic stem cell transplantation. Caspian J Intern Med. 2021; 12 (4) :6-0
URL: http://caspjim.com/article-1-2418-en.html


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Volume 12, Issue 4 (9-2021) Back to browse issues page
Caspian Journal of Internal Medicine
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