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:: Volume 13, Issue 1 (Winter 2022) ::
Caspian J Intern Med 2022, 13(1): 84-89 Back to browse issues page
Rectal vs. sublingual misoprostol in cesarean section: three‑arm, randomized clinical trial
Fatemeh Zahra Bagheri , Mahboobeh Azadehrah , Bizhan Shabankhani , Hooshang Akbari * , Ebrahim Nasiri Ferami
Mazandaran University of Medical Sciences, Sari, Iran , bagheri.z1994@gmail.com
Abstract:   (932 Views)
Background: Misoprostol is a myometrial stimulant with uterotonic properties and can be administered rectally, vaginally, or sublingually. Numerous studies have investigated the effect of misoprostol on the prevention and treatment of PPH (postpartum hemorrhage) after vaginal delivery, but its use to control PPH during cesarean section has not been widely studied.
Methods: In this clinical trial study, 180 pregnant women who were candidates for cesarean section were included in the study. They were divided into 3 groups of 60 people (sublingual misoprostol group, rectal misoprostol group, control group). In all three groups, the volume of blood lost was recorded in the checklist at the end of surgery. Data were entered into SPSS software and analyzed.
Results: The mean bleeding in the control group was 225.4±63.9, while it was 137.9±33.8   and 118.9±28.5 in the sublingual misoprostol group and rectal misoprostol group, respectively. We had significantly more bleeding in the control group (p<0.001) compared to the other two groups.
Conclusion: These results confirm the positive effect of misoprostol in reducing bleeding and show the superiority of using rectal misoprostol compared to other methods of reducing bleeding during cesarean section.
Keywords: misoprostol, rectal administration, sublingual administration, cesarean section, bleeding
Full-Text [PDF 180 kb]   (376 Downloads)    
Type of Study: Original Article | Subject: Obstetrics & Gynicology
Received: 2020/10/5 | Accepted: 2021/03/17 | Published: 2022/01/30
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Bagheri F Z, Azadehrah M, Shabankhani B, Akbari H, Nasiri Ferami E. Rectal vs. sublingual misoprostol in cesarean section: three‑arm, randomized clinical trial. Caspian J Intern Med. 2022; 13 (1) :84-89
URL: http://caspjim.com/article-1-2540-en.html


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Volume 13, Issue 1 (Winter 2022) Back to browse issues page
Caspian Journal of Internal Medicine
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