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Glucose Tolerance and lipid profile changes after surgical menopause
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| Shahla Yazdani, Majid Sharbatdaran, Mohammad Abedi Samakoosh, Zinatossadat Bouzari *, Zahra Masoudi |
| Department of Gynacology, Babol University of Medical Sciences, Babol, Iran |
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Abstract: (10977 Views) |
| Background: Bilateral salpingo-oophorectomy in women may lead to metabolic consequences in patients. This study was performed to determine the glucose tolerance and lipid profile after menopause resulting from bilateral salpingo-oophorectomy. Methods: From September 2011 to March 2013, 31 women participants aged 46-52 years who underwent hysterectomy and bilateral salpingo-oophorectomy for benign reasons were recruited. An oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol, low density lipoproteis (LDL), high density lipoprotein (HDL) was performed before and 6 months after surgery. Fasting insulin and 2-hour insulin levels, fasting insulin / glucose indexes and homeostasis model assessment HOMA indexes were also measured. Results: The mean age of the patients was 48.6±2.9 years.The mean 2-h glucose level in OGTT changed from 26.7 before surgery to 111.1 (P=0.030). The mean level of lipid profile before and after surgery for TG was 132.3 versus 181.2 (P=0.005), total cholesterol 177.4 versus 206.7 (P=0.0001) and LDL 98.4 versus 115.3 (P=0.003). The other variables showed no significant difference. Conclusion: The results indicate that lipid profile changes like increase of TG, total cholesterol and LDL should be considered before removing the ovary during hysterectomy in premenopausal women. |
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| Keywords: Salpingo-oophorectomy, Menopause, Glucose tolerance, Lipid profile |
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Full-Text [PDF 87 kb]
(2270 Downloads)
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Type of Study: Short Communication |
Subject:
Obstetrics & Gynicology
Received: 2014/03/11 | Accepted: 2014/03/11 | Published: 2014/03/11
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