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:: Volume 6, Issue 3 (7-2015) ::
Caspian J Intern Med 2015, 6(3): 148-151 Back to browse issues page
Resistance patterns of Escherichia coli causing urinary tract infection
Elaheh Ferdosi-Shahandashti, Mostafa Javanian, Masoomeh Moradian-Kouchakssaraei, Babak Yeganeh, Ali Bijani, Elahe Motevaseli, Fatemeh Moradiyan-Kouchakssaraei *
Babol University of Medical Sciences , M.Moradiyan20@yahoo.com
Abstract:   (8588 Views)

 Background: Urinary tract infection (UTI) is one of the most prevalent infectious diseases and Escherichia coli is its common cause. The aim of this study was to assess the resistance patterns of E.coli in urinary tract infections and to determine the susceptibility of E.coli to commonly used antimicrobials and also to evaluate the options for empirical treatment of UTI.

 Methods: This study was conducted in the Ayatollah Rouhani Teaching Hospital of Babol Medical Sciences University in North of Iran. Between January of 2013 to December 2013, antimicrobial susceptibility tests were done by disk diffusion and microdilution method. Growth of >=105 cfu/ml was considered as positive urine test. Ten commonly used antibiotics were examined for susceptibility test. Data and the results were collected and analyzed.

 Results: E.coli grew in 57 urine samples. Imipenem, ofloxacin, ciprofloxacin were the most sensitive antibiotics at 87.7%, 87.7% and 78.9% respectively. Whereas, cotrimoxazole, cefexime, cefotaxcime and ceftriaxone were the most resistant antibiotics. Antibiotic sensitivity of disk diffusion compared minimum inhibitory concentration (MIC) detected by microdilution had the sensitivity, specificity, positive predictive value and negative predictive value of 82%, 98%, 99% and 74%, respectively.

 Conclusion: Imipenem, ofloxacin and ciprofloxacin should be used in empirical therapy of UTI.

 

Keywords: Urinary Tract Infection, UTI, Escherichia coli, antibiotic susceptibility, antibiotic resistance, disk diffusion, micro dilution
Full-Text [PDF 350 kb]   (1667 Downloads)    
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2014/06/7 | Accepted: 2015/06/7 | Published: 2015/06/7
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Ferdosi-Shahandashti E, Javanian M, Moradian-Kouchakssaraei M, Yeganeh B, Bijani A, Motevaseli E et al . Resistance patterns of Escherichia coli causing urinary tract infection. Caspian J Intern Med. 2015; 6 (3) :148-151
URL: http://caspjim.com/article-1-331-en.html


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Volume 6, Issue 3 (7-2015) Back to browse issues page
Caspian Journal of Internal Medicine
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