[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Impact Factor 2022: 1.4
Cite Score 2022: 2.1
SJR 2022: 0.347
SNIP 2022: 0.545
Publication Charge
►Publication Fee
In Press
 In Press Articles
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 14, Issue 4 (Autumn 2023) ::
Caspian J Intern Med 2023, 14(4): 732-736 Back to browse issues page
Pregnancy outcomes of normal karyotype fetuses with increased nuchal translucency
Shirin Niroomanesh , Narges Nadimzadeh , Fatemeh Rahimi-Sharbaf , Mahboobeh Shirazi , Fatemeh Golshahi , Behrokh Sahebdel , Elham Feizabad
Department of Obstetrics and Gynecology, Yas hospital, Tehran university of medical sciences, Tehran, Iran , dr.narges.nadimzadeh@gmail.com
Abstract:   (630 Views)
Background: Although the association between first-trimester increased nuchal translucency (NT) and chromosomal defects is well-defined, there is little knowledge about the importance of increased NT in fetuses with normal karyotypes. Hence, this study was designed to evaluate outcomes of normal karyotype fetuses with increased NT.
Methods: This observational retrospective study was conducted on 720 pregnancies with increased NT (>3mm) at 11 to 13 weeks of gestational age in Yas Hospital, Tehran, Iran, from 2016 to 2020. Study outcomes were incidence of preeclampsia, intrauterine growth restriction) IUGR (, preterm labor, fetal anomaly, cardiac malformations, hydrops fetalis, abortion, and intrauterine fetal death (IUFD) in pregnancies without evident chromosomal karyotype abnormalities.
Results: Out of 720 participants who underwent karyotyping in the study center, 523 fetuses had normal karyotype results. In the pregnancies assessed for outcome, 357 (68.3%) reached live birth, 104 (19.9%) aborted, and 62 (11.9%) resulted in IUFD.
Study outcomes including preeclampsia (<0.001), IUGR (<0.001), preterm labor (<0.001), fetal anomaly (<0.001), cardiac malformations (<0.001), hydrops fetalis (0.017), abortion (<0.001), and IUFD (<0.001) resulted in a statistically significant difference in the distribution of cases across NT intervals.
Conclusion: This study demonstrated adverse pregnancy outcomes increased with increasing NT despite normal karyotyping. Hence, tight observation of mothers and fetuses should be done in normal karyotype fetuses with increased NT.
Keywords: Nuchal translucency, Fetal abnormalities, Preterm labor, Preeclampsia, IUGR, Hydrops fetalis
Full-Text [PDF 525 kb]   (275 Downloads)    
Type of Study: Original Article | Subject: Obstetrics & Gynicology
Received: 2022/01/20 | Accepted: 2022/04/13 | Published: 2023/09/6
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Niroomanesh S, Nadimzadeh N, Rahimi-Sharbaf F, Shirazi M, Golshahi F, Sahebdel B et al . Pregnancy outcomes of normal karyotype fetuses with increased nuchal translucency. Caspian J Intern Med 2023; 14 (4) :732-736
URL: http://caspjim.com/article-1-3330-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 14, Issue 4 (Autumn 2023) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.05 seconds with 40 queries by YEKTAWEB 4652