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Association of metformin and aspirin intake with mammographic breast density: a cross-sectional study
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Bita Eslami    , Ramesh Omranipour , Arvin Aryan , Leila Bayani , Mahboubeh Abedi , Sadaf Alipour * |
| Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran , sadafalipour@yahoo.com |
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Abstract: (350 Views) |
Background: Our purpose was to investigate the association between Mammographic breast density (MBD), a known strong marker for breast cancer and metformin and aspirin use and duration of use alone or simultaneously, in a sample of Iranian women considering other confounding factors.
Methods: In a cross-sectional study, 712 individuals were selected out of women referred to two university hospitals for screening mammography. Participants’ information was collected with a questionnaire. Four-category density scale (a = almost entirely fatty, b = scattered fibroglandular densities, c= heterogeneously dense, and d = extremely dense) was categorized as low (a&b) and high (c&d) density.
Results: The mean age of the participants was 49.80 ± 7.26 years. Sixty-five percent of women belonged to the high and 35% to the low MBD category. Both aspirin and metformin had a significantly negative association with MBD, however, when confounding factors were entered into the models, only aspirin after adjustment for age and BMI had an inverse association with MBD (OR = 0.53, 95% CI: 0.35-0.94). Simultaneous use of metformin and aspirin (OR = 0.44, 95 %CI: 0.17-1.12) was associated with lower MBD. Furthermore, in women who used metformin (OR = 0.23, 95% CI: 0.09-0.62) and aspirin (O R= 0.35, 95% CI: 0.17-0.72) for 2 to 5 years, MBD was significantly lower. However, after the adjustment of confounding factors, these associations were not statistically significant.
Conclusion: It seems metformin and aspirin intakes are associated with MBD. However, further studies with more sample size are needed.
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| Keywords: Aspirin, Metformin, Mammographic Breast density, Risk factor. |
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Full-Text [PDF 410 kb]
(184 Downloads)
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Type of Study: Original Article |
Subject:
Oncology
Received: 2022/08/27 | Accepted: 2022/11/5 | Published: 2023/09/15
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