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:: Volume 15, Issue 2 (Spring 2024) ::
Caspian J Intern Med 2024, 15(2): 287-293 Back to browse issues page
Correlation between antiphospholipid antibodies and renal involvement in children with Henoch-Schönlein purpura: A cross-sectional study
Mehrnoush Hassas Yeganeh , Reza Sinaei , Aye Yaraghi , Khosro Rahmani , Vadood Javadi Parvaneh , Reza Shiari , Hamid Hosseinzadeh
Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran , r.sinaei@kmu.ac.ir
Abstract:   (252 Views)
Background: Renal involvement is the most damaging long-term complication of Immunoglobulin-A (IgA) vasculitis. In the lack of a definite predictive biomarker for renal involvement, antiphospholipid antibodies (aPL) have been proposed in recent years.
Methods: In this prospective cohort of 48 pediatric patients who were admitted with IgA vasculitis from September 2015 to June 2017, two serum samples were taken 12 weeks apart to detect Anti-Phospholipid antibodies. All patients were followed-up for renal involvement for six months.
Results: Renal involvement occurred in 14 out of 48 patients with IgA vasculitis (29.16%). APLs were positive in nine out of 14 patients with IgA vasculitis and renal involvement (64.28%), in contrast to only six out of 34 patients with IgA vasculitis without renal involvement (17.64%). The presence of aPL antibodies was statistically associated with renal involvement (P=0.002).  Although, the relationship between both sex (P=0.025) and age (P=0.046) with aPL positivity was statistically significant, performing a modified logistic regression test, the odds ratio was significant between the groups with and without renal involvement only in term of age and aPL positivity).
Conclusion: The presence of aPL antibodies was statistically associated with renal involvement. We found a significant relationship between the age and aPL positivity. Hence, we need multicenter, more extensive cohort studies to reach a better and more accurate conclusion on the relationship between serum aPLs and renal involvement in IgA vasculitis patients.

 
Keywords: Child, IgA vasculitis, Henoch-Schönlein purpura, Antiphospholipid antibody.
Full-Text [PDF 431 kb]   (129 Downloads)    
Type of Study: Original Article | Subject: Pediatrics
Received: 2022/09/4 | Accepted: 2024/02/2 | Published: 2024/02/2
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Hassas Yeganeh M, Sinaei R, Yaraghi A, Rahmani K, Javadi Parvaneh V, Shiari R et al . Correlation between antiphospholipid antibodies and renal involvement in children with Henoch-Schönlein purpura: A cross-sectional study. Caspian J Intern Med 2024; 15 (2) :287-293
URL: http://caspjim.com/article-1-3644-en.html


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Volume 15, Issue 2 (Spring 2024) Back to browse issues page
Caspian Journal of Internal Medicine
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