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:: Volume 15, Issue 1 (Winter 2024) ::
Caspian J Intern Med 2024, 15(1): 101-108 Back to browse issues page
Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes
Atefeh Rahimi , Nastaran Moridi , Amin Golestani , Gholamreza Anani-Sarab , Fatemeh Salmani , Gholamhossein Yaqubi , Behzad Mesbahzadeh , Mohammad Ali Jalalifar , Mohammad Malekaneh , Seyed Mehdi Sajjadi
Cellular and molecular research center, Birjand University of medical sciences, Birjand, Iran , mehdi.sadjadi@bums.ac.ir
Abstract:   (433 Views)
Background: Diabetic retinopathy (DR) is expanding to epidemic levels globally due to the progressing prevalence of diabetes mellitus (DM). In this study, the association between factor V Leiden (FVL), MTHFRC677T, and FXIIIVal34Leu polymorphisms and diabetic retinopathy was investigated in Eastern Iran.
Methods: This case-control study enlisted the participation of 300 people (diabetic patients=100, diabetic retinopathy patients=100, healthy controls=100), and polymorphisms were examined by Tetra primer ARMS-PCR.
Results: The frequency of FVL (p=0.294) and FXIIIVal34Leu (P=0.349) polymorphism showed no significant results between the genotype frequency in the mentioned groups. In contrast, MTHFRC677T SNP was significantly different in diabetic patients and controls (P=0.008). The MTHFRC677T polymorphism was found to be connected with increased systolic blood pressure in patients who had the TT genotype (130.96±11.92mm/Hg; P=0.011).
Conclusion: Our study recommended that the MTHFRC677T polymorphism may offer to DR development. Studies with larger sample sizes and a wider spectrum of populations are authorized to verify this finding.

 
Keywords: Diabetic retinopathy, Factor V Leiden, MTHFR, Factor XIII, T-ARMS-PCR
Full-Text [PDF 620 kb]   (192 Downloads)    
Type of Study: Original Article | Subject: Hematology
Received: 2022/11/18 | Accepted: 2023/03/28 | Published: 2024/01/19
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Rahimi A, Moridi N, Golestani A, Anani-Sarab G, Salmani F, Yaqubi G, et al . Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes. Caspian J Intern Med 2024; 15 (1) :101-108
URL: http://caspjim.com/article-1-3754-en.html


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Volume 15, Issue 1 (Winter 2024) Back to browse issues page
Caspian Journal of Internal Medicine
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