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:: Volume 15, Issue 2 (Spring 2024) ::
Caspian J Intern Med 2024, 15(2): 273-279 Back to browse issues page
Eosinopenia as a prognostic factor of mortality for COVID-19 in end-stage kidney disease patients patients
Asmara I Gede Yasa , Agustriadi I Gusti Ngurah Ommy , Sujaya I Made , Thalib Salim Said , Lestari Rina , Fatrullah Suryani Padua , Widiasari Komang Sri Rahayu , Ajmala Indana Eva
Department of Internal Medicine, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia , yasa.asmara@unram.ac.id
Abstract:   (270 Views)
Background: The unique role of eosinophil in coronavirus disease 2019 (COVID-19) patients has been shown in several studies, but its role in end-stage kidney disease (ESKD) patients who contracted COVID-19 is less reported. This study investigated eosinopenia's predictive value as a mortality marker in ESKD patients with COVID-19.
Methods: It is a retrospective study of ESKD patients who contracted COVID-19 between May 2020 and October 2021 in West Nusa Tenggara General Hospital, Indonesia. Comparative analysis was carried out between the death dan survival group. Logistic regression analysis was done to investigate the role of eosinopenia on the outcome after controlling other significant variables.
Results: The analyses included one hundred fifteen confirmed COVID-19 in ESKD patients. The average age was 50, 53% of patients were males, 41% were newly diagnosed with ESKD, and the mortality rate was 25.2%. This study's prevalence of eosinopenia, high neutrophil-to-lymphocyte ratio (NLR), and high C-reactive protein (CRP) in the nonsurvivors was 51.4%, 39.3%, and 30.8%, respectively. Diastolic blood pressure <90 mmHg (P=0.004), respiratory rate >22 x/minutes (P=0.011), oxygen saturation <93% (P=0.008), NLR >6 (p<0.001), eosinophil count <0.01 x103/uL (p<0.001), CRP >20 mg/L (P=0.047), and isolation hemodialysis (HD) therapy (p<0.001) were independently associated with mortality of COVID-19 in ESKD patients. However, on multivariate logistic regression analysis, eosinopenia (P=0.019) and HD (P=0.001) were risk factors that remained significant prognostic mortality factors.
Conclusion: Eosinopenia was common in ESKD patients with COVID-19, particularly in the death group. Eosinopenia at admission and HD during hospitalization were risk factors for COVID-19 mortality in ESKD patients.

Keywords: COVID-19, Eosinophil, ESKD, Hemodialysis, Mortality.
Full-Text [PDF 535 kb]   (130 Downloads)    
Type of Study: Original Article | Subject: Nephrology
Received: 2023/03/25 | Accepted: 2024/02/2 | Published: 2024/02/2
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I Gede Yasa A, I Gusti Ngurah Ommy A, I Made S, Salim Said T, Rina L, Suryani Padua F, et al . Eosinopenia as a prognostic factor of mortality for COVID-19 in end-stage kidney disease patients patients. Caspian J Intern Med 2024; 15 (2) :273-279
URL: http://caspjim.com/article-1-3896-en.html

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Volume 15, Issue 2 (Spring 2024) Back to browse issues page
Caspian Journal of Internal Medicine
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