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:: Volume 6, Issue 2 (4-2015) ::
Caspian J Intern Med 2015, 6(2): 93-97 Back to browse issues page
Vitamin D status and distribution in patients with chronic obstructive pulmonary disease versus healthy controls
Behzad Heidari, Yahya Javadian *, Mahmoud Monadi, Yahya Dankoub, Alireza Firouzjahi
mobility impairment research center , javad835@yahoo.com
Abstract:   (6812 Views)

 Background: Vitamin D has a potential to modulate inflammatory response against noxious particles in patients with chronic obstructive pulmonary disease (COPD). The present study was conducted to determine the status of serum vitamin D in COPD versus healthy group.

 Methods: The patients presented to the outpatient pulmonary clinic of Ayatollah Rouhani Hospital, Babol Iran. Diagnosis of COPD was confirmed based on airflow limitation defined as FEV1/FVC ratio <70% and FEV1< 80% of predicted. All eligible patients aged ≥ 40 years old entered the study. Pulmonary infection, tuberculosis, pleural effusion, congestive heart failure, pulmonary hypertension and embolism, restrictive airway disease, conditions leading changes in vitamin D metabolism and absorption were excluded. Serum 25-hydroxyvitamin D (25-OHD) was determined by electrocheminluminescence method and levels <20, 20-29, and ≥30ng/ml were considered as deficiency, insufficiency, and sufficiency. In statistical analysis, the frequency of serum 25-OHD deficiency and insufficiency in patients were compared regarding age of ≤ 50 or >50 years old. All patients were males and age and sex-matched controls were selected among healthy subjects accompanied COPD patients.

 Results: Ninety patients and 100 controls with respective mean (±SD) age of 64.8±11.7 and 62.6±11.7 years old (P=0.19) were studied. Compared with control, proportions of serum 25-OHD deficiency and insufficiency in patients >50 years were higher and deficiency was lower (61.5% vs 87.5%, P=0.11).

 Conclusion: These findings indicate that a significant proportion of young COPD patients have insufficient serum 25-OHD. Regarding a positive relationship between 25-OHD and FEV1 in COPD, these findings highlight serum 25-OHD assessment in COPD for recognizing high risk patients.


Keywords: vitamin D, COPD, Deficiency, insufficiency
Full-Text [PDF 336 kb]   (1977 Downloads)    
Type of Study: Original Article | Subject: Pulmonology
Received: 2014/10/14 | Accepted: 2015/01/24 | Published: 2015/03/15
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Heidari B, Javadian Y, Monadi M, Dankoub Y, Firouzjahi A. Vitamin D status and distribution in patients with chronic obstructive pulmonary disease versus healthy controls. Caspian J Intern Med 2015; 6 (2) :93-97
URL: http://caspjim.com/article-1-420-en.html

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Volume 6, Issue 2 (4-2015) Back to browse issues page
Caspian Journal of Internal Medicine
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