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Caspian J Intern Med 2016, 7(1): 7-12 Back to browse issues page
The course and outcome of renal failure due to human leptospirosis referred to a hospital in North of Iran A follow-up study
Roya Ghasemian, Mehran Shokri, Atieh Makhlough *, Mohammad amin Suraki-Azad
Mazandaran University of Medical Science, Sari ,Iran. , makhloughatieh@gmail.com
Abstract:   (8747 Views)

Background: Renal complication of leptospirosis is common and its clinical manifestations vary from urinary sediment changes to acute renal failure. The aim of this study was to determine the final outcome of renal involvement in leptospirosis.

Methods: This longitudinal prospective study included all serologically confirmed cases of leptospirosis with evidence of renal failure. All patients were followed for three months while all patients with renal failure were followed-up for one year.

Results: Fifty-one patients, 53.5±14.8 years (82.4% males) with acute renal failure were studied. Over the hospitalization period, 28 patients recovered, and seven (13.72%) patients died of multiple organ failure. At the time of discharge, 16 patients had mild renal failure. Over the follow-up period, all patients recovered but in two patients renal failure persisted at creatinine level of 1.5 mg/dl.

Conclusion: Development of renal failure in leptospirosis is not rare. Recovery of renal function may last several months. However, most patients recover completely at least after one year.

Keywords: acute renal failure, chronic renal failure, hepatic dysfunction, leptospirosis, multiple organ failure
Full-Text [PDF 280 kb]   (2556 Downloads)    
Type of Study: Original Article | Subject: Nephrology
Received: 2015/01/15 | Accepted: 2015/10/5 | Published: 2015/11/9
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Ghasemian R, Shokri M, Makhlough A, Suraki-Azad M A. The course and outcome of renal failure due to human leptospirosis referred to a hospital in North of Iran A follow-up study . Caspian J Intern Med. 2016; 7 (1) :7-12
URL: http://caspjim.com/article-1-461-en.html

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Volume 7, Issue 1 (1-2016) Back to browse issues page
Caspian Journal of Internal Medicine
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