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:: Volume 7, Issue 2 (4-2016) ::
Caspian J Intern Med 2016, 7(2): 78-81 Back to browse issues page
Addition of clidinium-C to the 14-day proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication
Mohammadreza Seyyedmajidi, Saba Homapoor, Elahe Zanganeh, Mohammad Dadjou, Shahab Eskandari-Nejad, Mohammad-Hadi Tajik-Galayeri, Jamshid Vafaeimanesh *
Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran , j.vafaeemanesh@muq.ac.ir
Abstract:   (8547 Views)

Background: Triple therapy with a proton pump inhibitor and two antibiotics in Helicobacter pylori (HP) eradication is widely accepted, but this combination fails in a considerable number of cases. The aim of this study was to assess the effect of clidinium-C addition on HP eradication and to investigate the efficacy and safety of clidinium-C in prevention of drugs' side effects.

Methods: A total of 200 histopathologically confirmed HP positive peptic ulcer enrolled in this study which were randomly assigned to two treatment groups: OAC (20 mg omeprazole bid, 1000 mg amoxicillin bid and 500 mg clarithromycin bid) and OAC + clidinium-C. The effect of treatment and adverse effects were compared 6 weeks after completion of treatment. A13C-urea breath test was performed to confirm HP eradication.

Results: A total of 184 patients (90 in group A and 94 in group B) completed the treatment protocols. HP eradication was achieved in 71.1% in OAC versus 72.3% in OCA+clidinium-C, (P=0.73). The frequencies of abdominal pain and stool abnormality, among the side effects recorded during the therapy period, were significantly lower in group B (OCA+clidinium-C) (P=0.01 and P=0.001, respectively).

Conclusion: Addition of clidinium-C to OCA triple therapy decreases abdominal pain and frequency of stool abnormalities without affecting HP eradication rate. Based on these findings addition of clidinium-C may increase patient's compliance.

Keywords: Clidinium-C, Helicobacter pylori eradication, Peptic ulcer, Side effects
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Type of Study: Original Article | Subject: Gastroentrology
Received: 2013/12/30 | Accepted: 2015/09/15 | Published: 2016/03/8
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Seyyedmajidi M, Homapoor S, Zanganeh E, Dadjou M, Eskandari-Nejad S, Tajik-Galayeri M et al . Addition of clidinium-C to the 14-day proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication. Caspian J Intern Med 2016; 7 (2) :78-81
URL: http://caspjim.com/article-1-48-en.html

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Volume 7, Issue 2 (4-2016) Back to browse issues page
Caspian Journal of Internal Medicine
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