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:: Volume 6, Issue 3 (7-2015) ::
Caspian J Intern Med 2015, 6(3): 120-127 Back to browse issues page
Histological changes of kidney in diabetic nephropathy
Mohsen Pourghasem, Hamid Shafi *, Zahra Babazadeh
Fatemeh Zahra Infertility and Reproductive Research Center, Babol University of Medical Sciences, Babol, Iran , Hshafi@yahoo.com
Abstract:   (9683 Views)
  Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal tissue. It is believed that early histological changes in diabetic nephropathy are detectable 2 years after diabetes is diagnosed. The glumerular alterations are the most important lesions in the diabetic nephropathy (DN). The Renal Pathology Society provides a new pathological classification for the detection of histopathology of DN. It divides diabetic nephropathy into four hierarchical glomerular lesions. Alloxan or streptozotocin induced diabetic rat is the one most widely used specie to study DN. Histological changes in the rat DN closely resemble the human disease and the most information of this review was obtained through the study of rat DN. All cell types of the kidney such as mesangial cells, podocytes and tubulointerstitial cells are liable to be affected in the event of DN. Severity of renal lesions is associated to the clinical aspect of renal outcome, but the aim of this article was only to review the histological changes of kidney in diabetes mellitus. 
Keywords: Diabetic mellitus, nephropathy, histological changes
Full-Text [PDF 541 kb]   (2665 Downloads)    
Type of Study: Review Article | Subject: Nephrology
Received: 2015/04/20 | Accepted: 2015/05/20 | Published: 2015/05/20
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pourghasem M, Shafi H, Babazadeh Z. Histological changes of kidney in diabetic nephropathy. Caspian J Intern Med. 2015; 6 (3) :120-127
URL: http://caspjim.com/article-1-523-en.html


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Volume 6, Issue 3 (7-2015) Back to browse issues page
Caspian Journal of Internal Medicine
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