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:: Volume 8, Issue 2 (2-2017) ::
Caspian J Intern Med 2017, 8(2): 108-111 Back to browse issues page
Adding ofloxacin to standard triple-drug regimens increased the Helicobacter pylori eradication rate: Data from randomized clinical trial
Mahmoud Sadeghi-Hadad-Zavareh, Sayedsaied Mohammadi *, Mahmoud Hajiahmadi, Masoomeh Habibian
Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Scences, Babol, Iran , Ssmmbb293@yahoo.com
Abstract:   (7272 Views)

Background: The rate of Helicobacter pylori (H.pylori) eradication in dyspeptic patients using bismuth- based triple therapy is low due to bacterial that are resistant to antibiotics. The results of recent studies regarding levofloxacin have been encouraging, but the high cost of treatment prevents its routine administration. We, therefore, performed the present double-blind clinical trial to compare the efficiency of quadruple-drug regimen containing ofloxacin, clarithromycin, amoxicillin, and omeprazole and the same standard triple-therapy regimen minus ofloxacin in H. pylori positive dyspepsia.

Methods: The study patients were recruited among dyspeptic patients requiring gastroscopy. Patients with the history of H.pylori treatment, renal failure and pregnancy were excluded. Diagnosis of H.pylori infection was confirmed by rapid urease test and response to treatment was confirmed via negative urease breath test (UBT) 20 days after completion of treatment. Patients were allocated intermittently to standard triple therapy containing amoxicillin, clarithromycin, omeprazole alone or plus ofloxacin for ten days. Response to treatment was compared between the two groups.

Results: A total of 140 patients entered the study (70 patients in each group). At endpoint 30 (42.9%) patients of group 1 and 39 (55.7%) patients of group 2 became asymptomatic. Furthermore, 55 (78.6%) patients of group 1 and 66 (94.3%) patients of group 2 revealed negative urea breath test (P= 0.01).

Conclusion: This study indicates adding ofloxacin to standard triple-therapy for H.pylorri infection significantly increases the rate of eradication. These findings highlight ofloxacin as empiric treatment of H. pylori infection.

Keywords: Helicobacter pylori, Drug regimen, Ofloxacin
Full-Text [PDF 253 kb]   (1756 Downloads)    
Type of Study: Short Communication | Subject: Infectious Diseases
Received: 2015/06/7 | Accepted: 2016/07/11 | Published: 2016/09/10
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Sadeghi-Hadad-Zavareh M, Mohammadi S, Hajiahmadi M, Habibian M. Adding ofloxacin to standard triple-drug regimens increased the Helicobacter pylori eradication rate: Data from randomized clinical trial . Caspian J Intern Med. 2017; 8 (2) :108-111
URL: http://caspjim.com/article-1-555-en.html


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Volume 8, Issue 2 (2-2017) Back to browse issues page
Caspian Journal of Internal Medicine
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