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:: Volume 7, Issue 2 (4-2016) ::
Caspian J Intern Med 2016, 7(2): 88-92 Back to browse issues page
Altered plasma marker of oxidative DNA damage and total antioxidant capacity in patients with Alzheimer's disease
Ameneh Moslemnezhad , Soleiman Mahjoub , Mehdi Moghadasi
Fatemeh Zahra Infertility and Reproductive health Research Center , smahjoub20@gmail.com
Abstract:   (9217 Views)

Background: Recent studies have shown that oxidative stress (OS) is the most important indicator in the pathogenesis of Alzheimer's disease (AD), but the results in previous studies are conflicting. This study aimed to assess the plasma levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as DNA oxidative damage marker and total antioxidant capacity (TAC) in patients with AD versus control group.

Methods: Thirty patients with AD and 30 sex-and age-matched healthy subjects were studied. Diagnosis of AD was based on National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's disease and Related Disorders Association (NINCDS/ADRDA) criteria. Also for the patients, Mini-Mental State Examination (MMSE), computed tomography (CT) scan and brain magnetic resonance imaging (MRI) were done. Plasma levels of 8-OHdG and TAC were measured by competitive ELISA method and ferric reducing antioxidant power (FRAP) assay, respectively.

Results: Plasma levels of 8-OHdG was significantly higher in AD compared to control group (p<0.001), while the total antioxidant was significantly lower in patients compared to controls (p=0.002). The value of area under the ROC curve for 8-OHdG and TAC in discriminating AD from controls were 0.87 and 0.32, respectively.

Conclusion: Our results indicate a link between oxidative stress and AD indicating a possible contributive role of these markers in the development of AD and as an indicator in the discrimination of AD from healthy controls.

Keywords: Alzheimer\'s disease, Oxidative stress, DNA damage, 8-OHdG, TAC.
Full-Text [PDF 441 kb]   (2799 Downloads)    
Type of Study: Original Article | Subject: Biochimestry
Received: 2015/08/17 | Accepted: 2016/01/25 | Published: 2016/03/14
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Moslemnezhad A, Mahjoub S, Moghadasi M. Altered plasma marker of oxidative DNA damage and total antioxidant capacity in patients with Alzheimer's disease. Caspian J Intern Med 2016; 7 (2) :88-92
URL: http://caspjim.com/article-1-603-en.html


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Volume 7, Issue 2 (4-2016) Back to browse issues page
Caspian Journal of Internal Medicine
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