[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 7, Issue 3 (7-2016) ::
Caspian J Intern Med 2016, 7(3): 206-210 Back to browse issues page
Ability of serum C-reactive protein and white blood cell cout in predicting acute schemic stroke. A short -term follow-up study
Babak Bakhshayesh-Eghbali, Seyed-Ali Roudbary, Seddigheh Basir-Jafari, Seyedeh-Parand Nabizadeh, Naghmeh Naderi-Asrami, Reza Sohrabnejad *
Babol university , sohrabnejad_neuro@yahoo.com
Abstract:   (6391 Views)

Background: Stroke is one of the leading causes of mortality and long-term morbidity. The aim of the present study was to determine the ability of baseline serum C-reactive protein (CRP) and white blood cell count (WBC) values in predicting the outcome of acute ischemic stroke (AIS).

Methods: This study consisted of patients with first AIS referred to Poursina Hospital, Rasht, Iran. Severity of stroke was determined according to the National Institute of Health (NIH) Stroke Scale at the time of admission. Serum CRP levels and WBC count were measured at the time of admission. All patients were followed-up for 90 days after discharge and the severity of stroke was assessed using modified Rankin Scale. Receiver operating characteristic curve analysis was used for calculating the most appropriate cutoff point of CRP and WBC count for differentiating patients with and without poor outcome at the end of the study period.

Results: A total of 53 out of 102 patients (52%) had poor outcome. The most appropriate cutoff value for CRP in differentiating patients with and without poor outcome was 8.5mg/l (sensitivity: 73.1%, specificity: 69.4%) and for WBC the difference did not reach to a significant level. The cutoff points of CRP > 10.5 mg/ml yielded a predictive ability at sensitivity: 75%, specificity: 63.8% whereas predictive ability of WBC for mortality was at a borderline level.

Conclusion: These findings indicate that high levels of serum CRP in AIS at the time of admission is associated with poor prognosis. However, this study found no ability for WBC in predicting AIS outcome

Keywords: C reactive protein, Leukocytosis, Ischemic Stroke, Prognosis, National institutes of health stroke scale
Full-Text [PDF 268 kb]   (1760 Downloads)    
Type of Study: Original Article | Subject: Neurology
Received: 2015/09/23 | Accepted: 2016/01/12 | Published: 2016/06/8
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bakhshayesh-Eghbali B, Roudbary S, Basir-Jafari S, Nabizadeh S, Naderi-Asrami N, Sohrabnejad R. Ability of serum C-reactive protein and white blood cell cout in predicting acute schemic stroke. A short -term follow-up study. Caspian J Intern Med. 2016; 7 (3) :206-210
URL: http://caspjim.com/article-1-622-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 7, Issue 3 (7-2016) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4374