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Caspian J Intern Med 2017, 8(1): 35-43 Back to browse issues page
Effect of SeptimebTM as a new natural extract on severe sepsis: A randomized clinical trial
Alieh Pourdast, Maryam Sanaie, Sirous Jafari, Mostafa Mohammadi, Hossein Khalili, Gita Shafiee, Zeinab Ahadi, Mahsa Rostami, Saba Alizad, Ramin Heshmat *, Minoo Mohraz
Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , ahadi.ze@gmail.com
Abstract:   (7201 Views)

Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate.

Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily.

Results: Treatment with Septimeb showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P<0.001) and a significant increase in GCS value (14.46±0.88) compared to the control group (12.86±1.78) (P<0.001).  Improvements of these values can confirm the potential of Septimeb in the reduction of severity of sepsis (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07±34.80, control group: 51.75±42.10, P=0.98) and CRP (Septimeb group: 48.86±23.21, control group: 49.93±36.22, P=0.92) decreased, but did not show a significant reduction.

Conclusion: Septimeb has positive effects on reduction of the severity of sepsis which leads to reduction of patients’ mortality rates.

Keywords: Sepsis, Septimeb, Infection, Inflammatory
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Type of Study: Original Article | Subject: Infectious Diseases
Received: 2016/05/8 | Accepted: 2016/09/5 | Published: 2016/11/15
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Pourdast A, Sanaie M, Jafari S, Mohammadi M, Khalili H, Shafiee G, et al . Effect of SeptimebTM as a new natural extract on severe sepsis: A randomized clinical trial. Caspian J Intern Med. 2017; 8 (1) :35-43
URL: http://caspjim.com/article-1-755-en.html

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Volume 8, Issue 1 (1-2017) Back to browse issues page
Caspian Journal of Internal Medicine
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