Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Tue, Mar 18, 2025
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Volume 10, Issue 3 (6-2019)
Caspian J Intern Med 2019, 10(3): 271-275 |
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Kafi G, Akbarpour S, Arefi M, Behnoush B, Ahmadi Pishkuhi M, Barzegari N. Effect of hydroxyethyl starch on acidosis in patients with aluminum phosphide poisoning. Caspian J Intern Med 2019; 10 (3) :271-275
URL: http://caspjim.com/article-1-1594-en.html
URL: http://caspjim.com/article-1-1594-en.html
Gholamabbas Kafi 
, Samaneh Akbarpour , Mohammad Arefi * , Behnam Behnoush , Mahin Ahmadi Pishkuhi , Nasrin Barzegari
, Samaneh Akbarpour , Mohammad Arefi * , Behnam Behnoush , Mahin Ahmadi Pishkuhi , Nasrin Barzegari
Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , 3mohammadarefi@gmail.com
Abstract: (4805 Views)
Background: Given the fact that various studies have reported the positive effects of hydroxyethyl starch therapy in controlling shock, this study aimed to compare the effects of hydroxyethyl starch on modifying acidosis and treating patients with aluminum phosphide poisoning.
Methods: This was a randomized clinical trial that was conducted on 60 patients with aluminum phosphide poisoning. We compared the two groups of patients treated with hydroxyethyl starch and normal saline. Base excess and serum pH of arterial blood gases (ABG) were measured before and after the treatment and compared by t-test.
Results: Results showed that arterial pH in the starch group and normal saline group increased by 0.13 and 0.18, respectively, and the difference between the two groups was not statistically significant. The difference in the base excess before and after treatment in the starch group and normal saline group was 6.41 and 5.39, respectively, and the difference between the two groups was not statistically significant. Changes in mean values of arterial pH after the intervention in comparison with before treatment were statistically significant (p<0.05).
Conclusion: Overall, the results of the present study show that starch is at least as effective as normal saline in treating acidosis in patients poisoned with aluminum phosphide and can be used instead of normal saline, and both of the two treatments could be equally effective.
Methods: This was a randomized clinical trial that was conducted on 60 patients with aluminum phosphide poisoning. We compared the two groups of patients treated with hydroxyethyl starch and normal saline. Base excess and serum pH of arterial blood gases (ABG) were measured before and after the treatment and compared by t-test.
Results: Results showed that arterial pH in the starch group and normal saline group increased by 0.13 and 0.18, respectively, and the difference between the two groups was not statistically significant. The difference in the base excess before and after treatment in the starch group and normal saline group was 6.41 and 5.39, respectively, and the difference between the two groups was not statistically significant. Changes in mean values of arterial pH after the intervention in comparison with before treatment were statistically significant (p<0.05).
Conclusion: Overall, the results of the present study show that starch is at least as effective as normal saline in treating acidosis in patients poisoned with aluminum phosphide and can be used instead of normal saline, and both of the two treatments could be equally effective.
Type of Study: Original Article |
Subject:
Internal
Received: 2018/08/27 | Accepted: 2019/01/29 | Published: 2019/07/27
Received: 2018/08/27 | Accepted: 2019/01/29 | Published: 2019/07/27
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