Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Mon, Dec 16, 2024
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Volume 13, Issue 3 (Summer 2022)
Caspian J Intern Med 2022, 13(3): 519-526 |
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Motamed B, Kohansal Vajargah M, Kalantari S, Shafaghi A. HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis. Caspian J Intern Med 2022; 13 (3) :519-526
URL: http://caspjim.com/article-1-2695-en.html
URL: http://caspjim.com/article-1-2695-en.html
GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran , drafshinshafaghi@gmail.com
Abstract: (2732 Views)
Background: NAFLD is one of the most common liver diseases in the world. HOMA-IR as an indicator of insulin resistance is commonly used in clinical trials in NAFLD patients. The aim of this study was to evaluate the application of HOMA-IR index in the diagnosis of NAFLD.
Methods: This study was performed on 54 patients with NAFLD and 54 non-NAFLD patients that referred to Razi Hospital in Rasht during 2019-2020. FibroScan was used to diagnose NAFLD in the patient group and ultrasound was used to rule it out in the control group. Metabolic and hepatic parameters were measured for each patient. Data were entered into SPSS 22 software and the necessary analyses were performed.
Results: The mean age of the subjects in the study was 44.01±13.12 years and ranged from 18 to 75 years. 72.2% of people affected by NAFLD were men (p <0.001) .The optimal cut-off point for HOMA-IR in NAFLD was 1.65 with a sensitivity of 89.7% and a specificity of 76.9% in men and 1.90 with a sensitivity of 86.7% and a specificity of 82.9% in women. Overall, the optimal cut-off point for HOMA-IR in NAFLD was 1.75 with a sensitivity of 87.0% and a specificity of 81.5%. In addition, the results showed that there was no significant relationship between steatosis and hepatic fibrosis with HOMA-IR index.
Conclusion: The results showed that HOMA-IR can be used as a reliable criterion for early detection of NAFLD.
Methods: This study was performed on 54 patients with NAFLD and 54 non-NAFLD patients that referred to Razi Hospital in Rasht during 2019-2020. FibroScan was used to diagnose NAFLD in the patient group and ultrasound was used to rule it out in the control group. Metabolic and hepatic parameters were measured for each patient. Data were entered into SPSS 22 software and the necessary analyses were performed.
Results: The mean age of the subjects in the study was 44.01±13.12 years and ranged from 18 to 75 years. 72.2% of people affected by NAFLD were men (p <0.001) .The optimal cut-off point for HOMA-IR in NAFLD was 1.65 with a sensitivity of 89.7% and a specificity of 76.9% in men and 1.90 with a sensitivity of 86.7% and a specificity of 82.9% in women. Overall, the optimal cut-off point for HOMA-IR in NAFLD was 1.75 with a sensitivity of 87.0% and a specificity of 81.5%. In addition, the results showed that there was no significant relationship between steatosis and hepatic fibrosis with HOMA-IR index.
Conclusion: The results showed that HOMA-IR can be used as a reliable criterion for early detection of NAFLD.
Type of Study: Original Article |
Subject:
Gastroentrology
Received: 2021/01/6 | Accepted: 2021/03/17 | Published: 2022/06/1
Received: 2021/01/6 | Accepted: 2021/03/17 | Published: 2022/06/1
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