Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Jan 2, 2025
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Volume 15, Issue 4 (Autumn 2024)
Caspian J Intern Med 2024, 15(4): 579-588 |
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Sheikhi M, Siyadat P, Rostami M, Sadeghian M H, Zahiri E, Ghorbani M, et al . Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis. Caspian J Intern Med 2024; 15 (4) :579-588
URL: http://caspjim.com/article-1-4000-en.html
URL: http://caspjim.com/article-1-4000-en.html
Maryam Sheikhi 
, Payam Siyadat , Mehrdad Rostami , Mohammad Hadi Sadeghian , Elnaz Zahiri , Mohammad Ghorbani , Hossein Ayatollahi , Amirali Ayatollahi , Reza Hemmatan Attarbashi , Zahra Khoshnegah *
, Payam Siyadat , Mehrdad Rostami , Mohammad Hadi Sadeghian , Elnaz Zahiri , Mohammad Ghorbani , Hossein Ayatollahi , Amirali Ayatollahi , Reza Hemmatan Attarbashi , Zahra Khoshnegah *
Department of Hematology and Blood Banking, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran. , zkhoshnegah@gmail.com
Abstract: (700 Views)
Background: NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. Despite substantial research illuminating the roles of NUP98 fusions in the course of AML, their impacts on the outcome of patients with AML should be explored in more detail. As a result, this meta-analysis was designed to provide further light on the prognostic implications of NUP98 fusions in AML.
Methods: We completed an extensive search in PubMed, Scopus, and Web of Science to identify papers evaluating the prognostic effects of NUP98 rearrangements in patients with AML until August 22, 2022. In total, 15 publications with 6142 participants fulfilled the requirements for the current meta-analysis. All the qualified studies were examined for information regarding HRs and 95% confidence interval (95%CI) for overall survival (OS) and event-free survival (EFS). In addition, we utilized Comprehensive Meta-analysis software version 2 (CMA2) for calculating pooled HRs and 95% CI.
Results: Our analyses for NUP98-NSD1 indicated that this fusion could significantly impact the outcome of patients with AML (pooled HR: 2.84; 95% CI: 2.49–3.24, P=0.000). Additionally, we observed a strong correlation between NUP98-KDM5A rearrangement and poor prognosis in AML (pooled HR: 2.65; 95% CI: 2.5-2.81; P=0.000). A subgroup analysis also showed that the NUP98-NSD1 and FLT3-ITD together confer a poor prognostic effect (pooled HR: 2.60, 95% CI: 1.61-4.18; P=0.000).
Conclusions: NUP98 fusions could significantly impact the outcome of patients with AML. The use of these fusions as prognostic indicators in AML seems rational.
Methods: We completed an extensive search in PubMed, Scopus, and Web of Science to identify papers evaluating the prognostic effects of NUP98 rearrangements in patients with AML until August 22, 2022. In total, 15 publications with 6142 participants fulfilled the requirements for the current meta-analysis. All the qualified studies were examined for information regarding HRs and 95% confidence interval (95%CI) for overall survival (OS) and event-free survival (EFS). In addition, we utilized Comprehensive Meta-analysis software version 2 (CMA2) for calculating pooled HRs and 95% CI.
Results: Our analyses for NUP98-NSD1 indicated that this fusion could significantly impact the outcome of patients with AML (pooled HR: 2.84; 95% CI: 2.49–3.24, P=0.000). Additionally, we observed a strong correlation between NUP98-KDM5A rearrangement and poor prognosis in AML (pooled HR: 2.65; 95% CI: 2.5-2.81; P=0.000). A subgroup analysis also showed that the NUP98-NSD1 and FLT3-ITD together confer a poor prognostic effect (pooled HR: 2.60, 95% CI: 1.61-4.18; P=0.000).
Conclusions: NUP98 fusions could significantly impact the outcome of patients with AML. The use of these fusions as prognostic indicators in AML seems rational.
Type of Study: Review Article |
Subject:
Hematology
Received: 2023/07/2 | Accepted: 2023/11/26 | Published: 2024/08/9
Received: 2023/07/2 | Accepted: 2023/11/26 | Published: 2024/08/9
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