Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Mon, Jun 16, 2025
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Volume 16, Issue 3 (Summer 2025)
Caspian J Intern Med 2025, 16(3): 437-443 |
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Aghapour S R, Mohammadi H, Aghapour S P, Farnoud K, Sharifzadeh Y. Comparing the results of knee osteoarthritis treatment with intra-articular injection of steroid (methylprednisolone) and hyaluronic acid. Caspian J Intern Med 2025; 16 (3) :437-443
URL: http://caspjim.com/article-1-4241-en.html
URL: http://caspjim.com/article-1-4241-en.html
Seyyed Reza Aghapour 
, Hamid Mohammadi , Seyyed Poyan Aghapour * , Khashayar Farnoud , Yasin Sharifzadeh
, Hamid Mohammadi , Seyyed Poyan Aghapour * , Khashayar Farnoud , Yasin Sharifzadeh
Sari Branch, Islamic Azad University, sari, Iran , dr.aghapour@gmail.com
Abstract: (8 Views)
Background: Treatments for osteoarthritis, including steroids and nonsteroidal anti-inflammatory drugs, are not very satisfactory. Therefore, we decided to compare the therapeutic results of intra-articular injection of hyaluronic acid and methylprednisolone.
Methods: In this single-blind clinical trial, 132 patients with osteoarthritis of the knee were randomly assigned to two treatment groups; hyaluronic acid and methylprednisolone. Treatment results were measured based on the standard McMaster Universities Arthritis Index (WOMAC) questionnaire.
Results: Although the desired level of satisfaction was higher in the short-term in the methylprednisolone group and in the long-term in the hyaluronic acid group, however, these differences were not significant.
Conclusion: The recovery of patients is better with methylprednisolone injection in the short term and hyaluronic acid in the long term. However, since methylprednisolone has complications, it is recommended to consider hyaluronic acid as a suitable drug in the treatment process.
Methods: In this single-blind clinical trial, 132 patients with osteoarthritis of the knee were randomly assigned to two treatment groups; hyaluronic acid and methylprednisolone. Treatment results were measured based on the standard McMaster Universities Arthritis Index (WOMAC) questionnaire.
Results: Although the desired level of satisfaction was higher in the short-term in the methylprednisolone group and in the long-term in the hyaluronic acid group, however, these differences were not significant.
Conclusion: The recovery of patients is better with methylprednisolone injection in the short term and hyaluronic acid in the long term. However, since methylprednisolone has complications, it is recommended to consider hyaluronic acid as a suitable drug in the treatment process.
Type of Study: Original Article |
Subject:
Orthopedy
Received: 2024/01/11 | Accepted: 2024/07/7 | Published: 2025/06/20
Received: 2024/01/11 | Accepted: 2024/07/7 | Published: 2025/06/20
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