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:: Volume 7, Issue 2 (4-2016) ::
Caspian J Intern Med 2016, 7(2): 114-119 Back to browse issues page
Multidrug resistance pattern of bacterial agents isolated from patient with chronic sinusitis
Mohammad-sadegh Rezai, Rostam Pourmousa , Roksana Dadashzadeh, Fatemeh Ahangarkani
Mazandaran Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. , drmsrezaii49@gmail.com
Abstract:   (5885 Views)

Background: Treatment of chronic sinusitis is complicated due to increase of antibiotic-resistant bacteria. The aim of this study was to determine the multidrug resistance (MDR) pattern of the bacteria causing chronic sinusitis in north of Iran.

Methods: This cross-sectional study was carried out on patients with chronic sinusitis. Bacterial susceptibility to antimicrobial agents was determined according to the CLSI 2013 standards. Double-disk synergy (DDS) test was performed for the detection of extended-spectrum beta-lactamase (ESBL) producing bacteria; also methicillin-resistant Staphylococcus (MRSA) strains were identified by MRSA screen agar.  The MDR isolates were defined as resistant to 3 or more antibiotics. Data were analyzed using SPSS 17 software. Descriptive statistics was used to describe the features of the data in this study.

Results: The rate of ESBL-producing bacteria was 28.75-37.03% among enterobacteriaceae and the rate of MRSA was 42.75%-60% among Staphylococcus strains. The most detectable rate of the MDR bacterial isolates was Gram-negative bacteria 39 (76.47%) and Enterobacter spp. 19(70.37%) was the most multidrug resistant isolate among Gram negative bacteria. Also 36 (73.46%) of the gram positive bacterial isolated were multidrug resistance and Staphylococcus aureus 9(90%) was the most MDR among Gram positive bacteria.

Conclusion: Antimicrobial resistance is increasing in chronic bacterial sinusitis. The emergence of MRSA and ESBL bacteria causing chronic sinusitis is increasing

Keywords: Chronic sinusitis, Bacteria, Antibiotic resistance, MRSA, ESBL, MDR
Full-Text [PDF 388 kb]   (1111 Downloads)    
Type of Study: Original Article | Subject: Microbiology
Received: 2015/06/27 | Accepted: 2015/12/14 | Published: 2016/03/14
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Rezai M, Pourmousa R, Dadashzadeh R, Ahangarkani F. Multidrug resistance pattern of bacterial agents isolated from patient with chronic sinusitis. Caspian J Intern Med. 2016; 7 (2) :114-119
URL: http://caspjim.com/article-1-575-en.html


Volume 7, Issue 2 (4-2016) Back to browse issues page
Caspian Journal of Internal Medicine
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