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Caspian J Intern Med 2012, 3(3): 488-495 Back to browse issues page
Methodological issues of confounding in analytical epidemiologic studies
Karimollah Hajian Tilaki *
Abstract:   (6941 Views)
Background: Confounding can be thought of as mixing the effect of exposure on the risk of disease with a third factor which distorts the measure of association such as risk ratio or odds ratio. This bias arises because of complex functional relationship of confounder with both exposure and disease (outcome). In this article, we provided a conceptual framework review of confounding issues in epidemiologic studies, in particular in observational studies and nonrandomized experimental studies. We have shown in 2 by 2 tables with analytical examples how the index of association will be distorted when confounding is present. The criteria, source of confounding and several points in confounding issues have been addressed. The advantages and disadvantages of several strategies for control of confounding have been discussed.
Keywords: Confounding, Bias, Observational studies, Non-randomized experimental studies, Risk ratio, Statistical models, Adjustment
Full-Text [PDF 120 kb]   (1872 Downloads)    
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15
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Hajian Tilaki K. Methodological issues of confounding in analytical epidemiologic studies. Caspian J Intern Med. 2012; 3 (3) :488-495
URL: http://caspjim.com/article-1-162-en.html

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Volume 3, Issue 3 (1-2012) Back to browse issues page
Caspian Journal of Internal Medicine
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