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Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial
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Mina AkbariRad    , Zahra Mazloum Khorasani , Behnam Beizae , Hossein Ayatollahi , Maryam Emadzadeh , Mehrdad Sarabi , Nikoo Saeedi , Negar Nekooei |
| Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , MazloumZ@mums.ac.ir |
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Abstract: (691 Views) |
Background: The current study intends to assess the impact of oral selenium intake on anti-Tg antibody in individuals with autoimmune hypothyroidism.
Methods: In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; One group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software.
Results: After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant.
Conclusion: Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group. |
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| Keywords: Anti-Tg antibody, Selenium, Autoimmune hypothyroidism.idism |
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Full-Text [PDF 494 kb]
(217 Downloads)
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Type of Study: Original Article |
Subject:
Endocrinology
Received: 2022/07/19 | Accepted: 2024/02/24 | Published: 2024/02/24
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